Clinical Trials & Research

Researchers determine whether oral corticosteroids, such as prednisolone,  reduce symptom duration or severity for acute lower respiratory tract infection in non-asthmatic adults. Acute lower respiratory tract infection (LRTI), defined as an acute cough with at least one of the symptoms of sputum, chest pain, shortness of breath, and wheezing is one of the most common
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Behavioural intervention can help decrease psychological distress among women with a history of gender-based violence. A clinical trial determines the effectiveness of a community-taught behavioral treatment on psychological distress. Gender-based violence toward women has been linked to increased mental stress and psychological morbidity in low and middle-income countries worldwide, specifically in urban Kenya. The treatment
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Given that the vast majority of opiate-dependent individuals relapse soon after detoxification, a recent study investigated whether the use of medications could assist in reducing the severity of opiate withdrawal. With over 11 million heroin users worldwide, the global health burden of opiate-dependent individuals remains high. Opiates are a class of drugs (including illicit drugs
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Despite the availability of chemotherapeutic agents for the treatment of acute lymphoblastic leukemia, some patients won’t respond to the drugs or experience relapse.  A phase 3 clinical trial examined the safety profile of inotuzumabozogazamin, a novel chemotherapeutic drug which has a potential to be used for relapsed and refractory acute lymphoblastic leukemia.   There are
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  In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms.   Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound
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Metabolic syndrome and non alcoholic fatty liver disease are conditions that are becoming more prevalent due to an increase of fructose and fats in our diets. A new study examines the role of citrulline in preventing endotoxin-induced injury in a rat model of non alcoholic fatty liver disease and finds that citrulline is able to prevent an inflammatory
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Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence. Stress urinary incontinence, or
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The National Audit Office (NAO) published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence, leading to a backlog, by the NHS Shared Business Services (NHS SBS). The National Audit Office (NAO) in the United Kingdom published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence by
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A recent study published in JAMA Psychiatry found that some adolescents, especially males, who lived in disadvantaged neighbourhoods showed abnormal changes in brain structure from early to late adolescence.   Positive parenting may protect against changes in brain structure, counteracting the biological and functional consequences associated with disadvantage. The biological, psychological, and social consequences of socioeconomic
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A study recently published in the American Journal of Clinical Nutrition explored various factors associated with inflammation in preschool children and women of reproductive age. It was found that recent illness and obesity were consistently associated with inflammation regardless of environment, while commonly measured demographic covariates, such as sex or socioeconomic status, were not. Triggered
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A new study finds that using soluble transferrin receptor (sTfR) concentrations to estimate nutritional iron deficiency anemia may be inaccurate as sTfR levels are affected in the presence of inflammation and malaria. The study proposes methods to adjust measured sTfR values when inflammation or malaria are present, so that these values reflect nutritional iron deficiency
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A recent New England Journal of Medicine article reports that Rivaroxaban has greater efficacy and more acceptable side effects than Aspirin in patients with recurrent venous thromboembolisms. Thrombose, the formation of blood clots, is a medical emergency that requires prompt medical attention. Three factors, commonly referred to as the Virchow triad, contribute to the formation
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Tuberculosis is a communicable respiratory disease. A group of researchers led by Maeve Lalor conducted a cohort study to determine household transmission of tuberculosis in England by combining epidemiologic and molecular strain typing data. Tuberculosis is a communicable respiratory disease prevalent in some third world countries. In first world countries where the prevalence of this
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A recent study explored the antibacterial effects of modified forms of vancomycin on antibiotic-resistant bacteria. The results suggest C1-aminomethylene vancomycin may be an effective agent against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic-resistant bacteria.   The ability of bacterial strains to acquire resistance to antibiotics faster than antibacterial therapies can be developed is of growing
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Researchers from Duke University in North Carolina produced pathogen-resistant crops without compromising the plant’s yield and fitness.   Plants are commonly attacked by microbial, viral or fungal pathogens. Improving crop production involves the applications of pesticides. In recent years, genetically modified pathogen-resistant crops that express a high level of immune proteins have been produced. One
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In case you missed it, here are the biggest headlines of the week! Effects of Mediterranean Diet on Endothelial Function and Blood Pressure A group of researchers conducted a randomized control trial to determine whether adherence to Mediterranean diet improved endothelial function and lowered blood pressure levels … [read more]   Is Ketamine with Electroconvulsive
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The Canadian government, under Prime Minister Justin Trudeau, plans on passing new legislation that will legalize recreational marijuana use across Canada for anyone over the age of 18. Despite wide public support, some policy makers and politicians have concerns regarding the logistics and wholesome regulation of recreational marijuana.   Legalizing recreational marijuana has been a
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