Clinical Trials & Research

Our Reader Score [Total: 0 Average: 0] Due to a complex and poorly understood mechanism of action, only two medications are currently approved for the treatment of ALS.  A multicentre trial was recently carried out in Germany to determine whether rasagiline could improve survival rates in patients with ALS when used with one of these
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Our Reader Score [Total: 0 Average: 0] A clinical trial that used sildenafil (Viagra) to treat pregnant women with fetal growth restriction was stopped early due to deaths. Severe early-onset fetal growth restriction is a complication that occurs in about 0.4% of pregnant woman and usually results in the birth of a premature baby, a
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Our Reader Score [Total: 1 Average: 5] A recent study in the NEJM describes the outcome of a large clinical trial that compared cardiovascular risks of febuxostat or allopurinol for gout treatment. Gout is a kind of arthritis that occurs due to the formation of urate crystals within the bone joints. Uric acid, a substance
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Our Reader Score [Total: 3 Average: 2.3] A group of researchers in the US modified the existing chemotherapy with humanized antibodies to improve lung cancer survival rates. Lung cancer is the leading cause of death from cancer in Canada. According to The Canadian Cancer Society, about 28,600 Canadians were diagnosed with lung cancer in 2017.
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Our Reader Score [Total: 0 Average: 0] A clinical trial of stroke treatments showed that giving three antiplatelet therapy drugs had no benefit over two, and was associated with more bleeding. Recent large-scale clinical trials have shown that starting treatment with two antiplatelet therapy drugs after a stroke, rather than just one, reduces the risk
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Our Reader Score [Total: 1 Average: 5] Stem cell clinical trials have the potential to treat and cure genetic and degenerative diseases. However, many recent trials have sacrificed scientific quality and health safety to push quicker clinical trials. Concerned researchers advocating for better clinical trial have proposed new guidelines to deter substandard clinical trials. Stem
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Our Reader Score [Total: 1 Average: 2] A recent trial testing the effectiveness of rivaroxaban against aspirin in recurrent stroke prevention was terminated due to risk-benefit concerns. Ischemic strokes occur when blood vessels in the brain become obstructed by blood clots. Approximately 1 in 5 strokes are of the embolic subtype, meaning that the blood
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Our Reader Score [Total: 1 Average: 4] Most treatments for multiple sclerosis concentrate on managing symptoms and slowing disease progression. A recent phase-3 trial investigated whether natalizumab is effective in treating secondary progressive multiple sclerosis. Canada has one of the highest incidences of multiple sclerosis (MS) worldwide. An autoimmune disease, MS targets the protective covering
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Our Reader Score [Total: 0 Average: 0] The results of a phase-3 trial were recently published comparing the effectiveness of postoperative chemotherapy with chemoradiotherapy for gastric cancer. Gastric carcinoma is a form of cancer that originates in the lining of the stomach. This form of cancer is rare in comparison to other types of cancer.
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Our Reader Score [Total: 0 Average: 0] Investigator brochures are key documents in the regulatory approval process before initiating clinical trials. A recent study by German and Canadian researchers investigated just how effective these documents are at enabling accurate risk-benefit assessments. The main purpose of early-phase clinical research is to establish the safety and dosing
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Our Reader Score [Total: 0 Average: 0] Despite being the gold standard, a recent publication in Annals of Medicine suggests that randomized controlled trials may not be as unbiased as scientists believe. Randomization is an important element of modern clinical trials. It refers to the process of randomly allocating participants to either the experimental or
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A phase-1b trial funded by Merck and Pfizer combined two drugs to evaluate their effectiveness in treating renal cell carcinoma. Renal cell carcinoma makes up 95% of kidney cancer cases. About 338,000 cases of renal cell carcinoma are detected worldwide every year. Renal cell carcinoma is a form of cancer that starts in the small tubules
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A recent study investigated whether pimavanserin, a treatment for Parkinson’s disease psychosis, could also treat Alzheimer’s disease psychosis. Of the approximate 45 million people worldwide suffering from Alzheimer’s disease, between 25-50% of these individuals will at some point also suffer from symptoms of psychosis, the most common being hallucinations and delusions. Psychosis is an impaired relationship
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In a recent study, researchers examined the effects of amobarbital and N-acetylcysteine on post-traumatic osteoarthritis in injured joints. Injury to load-bearing joints such as the knees or ankles can result in posttraumatic osteoarthritis (PTOA), a condition in which the shock-absorbing and friction-reducing joint cartilage breaks down over time. Evidence suggests that metabolic changes in cartilage-producing
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Researchers attempt to identify a therapeutic target that encourages respiratory muscle relaxation to provide asthma relief. Asthma causes respiratory problems, which can manifest as wheezing and chest tightness. It is a common affliction that affects about 10% of the US population. There has been much research focused on discovering therapeutic targets for asthma relief, such
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A recent article in The Lancet showcases encouraging results from two Zika virus gene-based vaccine candidates being developed in the USA. The Zika virus is a growing global health concern. Outbreaks of the Zika virus occurred in 2006, 2013, and 2015 on different continents across the world. There is currently no vaccine available for the
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Researchers in the US determine whether an antibody drug, solanezumab, can slow cognitive decline in patients with mild dementia. Alzheimer’s disease is thought to arise from a buildup of amyloid-beta (Aβ) plaques and neurofibrillary tangles in the brain. Those with Alzheimer’s disease may also show signs of mild dementia. The Aβ hypothesis suggests that Aβ
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Recent phase 3 clinical trials compared the efficacy and safety of a novel two-drug regimen, with the standard three-drug antiretroviral therapy for HIV. Antiretroviral therapy (ART), comprised of two nucleoside reverse transcriptase inhibitors (NRTIs) and a third drug, is the first- and second-line treatment for patients with an HIV infection. The use of NRTIs is
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An episodic migraine is a debilitating headache disorder with few effective and safe preventative treatments available. Researchers in this study conducted a trial on erenumab, to determine its effectiveness in providing relief for people suffering from episodic migraines. Migraines are defined as a debilitating headache disorder that manifests as a throbbing headache which can last
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Researchers at Spark Therapeutics and Pfizer tested the safety and efficacy of a new hemophilia gene therapy vector for the treatment of hemophilia B. The body’s ability to stop bleeding and repair damaged blood vessels depends heavily upon a variety of clot-forming enzymes. Deficiency in one such enzyme, coagulation factor IX, results in the development
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Scientists are investigating the effectiveness of using galcanezumab to prevent migraines, a monoclonal antibody that targets the proteins involved in migraine pathophysiology. Migraines are chronic, debilitating headaches that can last a few hours or up to a few days. The cost to migraine sufferers is quite high when considering absenteeism from school or work and
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In a recent multinational clinical trial, researchers evaluated the effectiveness of two fremanezumab regimens for chronic migraine prevention. The transmission of pain signals during migraines is thought to be carried out in part by the release of calcitonin gene-related peptide (CGRP) from one nerve and reception by the next. Early trials have shown that fremanezumab,
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A recent study evaluated the effectiveness of using a subcutaneous injection to prevent postherpetic neuralgia, a common complication of shingles. Chickenpox is a common childhood infection caused by the herpes zoster virus. However, once the rash caused by the virus has cleared up, the virus can lay dormant for years. Later in life, or due
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A clinical trial involving patients with heart diseases has revealed new dimensions of the role of anti-inflammatory medications in preventing heart attacks. Like many diseases, it’s been proven that inflammation can be an underlying predisposing factor for cardiovascular diseases including heart attacks and strokes. Investigations about the role of inflammatory pathways in developing cardiovascular disease
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Researchers test the safety and efficacy of a natural anti-fungal treatment derived from spirulina to treat severe fungal infections of the skin and nails. Superficial fungal infections of the hair, skin, or nails, also referred to dermatophytosis, affects about a quarter of the world’s population. Topical anti-fungal treatment creams can be used to treat dermatophytosis,
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The NIH has amended its definition of clinical trials to include brain studies, introducing new regulations considered unnecessary by many researchers. The National Institutes of Health (NIH) has implemented its controversial decision to broaden the scope of clinical trials to include cognitive and behavioural studies. This change, which has been in discussion since at least
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