Cancer

A recent study reports that a high-fiber diet during radiation therapy for pelvic cancer helps reduce gastrointestinal radiation toxicity both immediately and over the long term compared to habitual fiber intake. This finding contravenes existing practice that recommends low-fiber diets to people undergoing pelvic radiation therapy. Radiation therapy is commonly used to treat abdominal and
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An analysis of germline mutation status predicting therapy response results from the GeparSixto trial looked into the efficacy of the treatment regimen for patients with triple-negative breast cancer. Triple-negative breast cancer (TNBC) patients carrying a germline mutation demonstrate better pathological complete response (pCR) and disease-free survival (DFS) rates under the anthracycline, taxane, and bevacizumab regimen.
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A group of researchers compared the biosimilar monoclonal antibody CT-P10 to the currently used rituximab in the treatment of follicular lymphoma. Non-Hodgkin Lymphoma (NHL) is a blood cancer characterized by the aberrant growth and multiplication of white blood cells (lymphocytes). Cancerous lymphocytes can migrate to and from tumors in different parts of the body, including
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Surgical tumor removal followed by stereotactic radiosurgery significantly lowers rates of tumor recurrence compared with tumor removal alone.   Cancer metastases to the brain are a major healthcare burden. For single metastases, surgical removal of the tumor followed by whole brain radiotherapy (WBRT) is the standard of care and has been shown to improve survival
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A recent study reports an association between low levels of vitamin A (Retinol), vitamin E and retinol binding protein (RBP4) and a poor prognosis for renal cell carcinoma.   Renal cell carcinoma is the most prevalent kidney cancer in adults, and it refers to various tumors in the nephron tissue (kidney tubular structures mediating transport
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First-line treatments for blood cancers include chemotherapy. Subsequent treatments may include stem cell therapy as a final line of defense. However, as discussed in a recent article in Science Health, the effects of this treatment can be just as devastating as the cancer in approximately 50% of patients.   Stem cell therapy is a two-step
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A recent study tests a multi-gene classifier, an ultralow-risk threshold, to determine if it can identify indolent tumours and breast cancer risk. Breast cancer is a life-threatening medical condition resulting in a wide range of outcomes. Recurrence of a tumour following initial diagnosis can range from a few months to several years. Molecular profiling is
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Nivolumab is an immune checkpoint inhibitor used in the treatment of melanoma. In an article published in JAMA Oncology, a group of researchers analyzed data from phase 3 clinical trials assessing the effects of nivolumab on patients with advanced melanoma treated beyond disease progression.   Nivolumab is a human monoclonal antibody which functions as an
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Mammography screening is touted as the best tool to detect early-stage breast cancer. A recent study looked at American women’s awareness of the benefits and risks associated with mammograms and whether these would influence their decision to undergo mammography. Breast cancer is a leading cause of cancer death in women worldwide. Early-stage breast cancer can
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A recent meeting of 21 scientists updated guidelines on several chemicals and their potential in causing urinary tract cancer.  The most current evidence is awaiting publication, recommending that 7 different substances be categorized as “possibly carcinogenic to humans”. Cancer arises when cells in our bodies undergo genetic damage or a disruption of normal cellular process
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A recently published report shows that high intake of the dietary omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid could increase your risk for colorectal adenoma (precancerous polyps that can develop into cancer).   Colorectal cancer is the second most common type of cancer, accounting for 13% of all cancers.1 With improved endoscopic screening for adenomas, the
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A small-molecule drug inhibitor called vismodegib successfully treated a dire case of infiltrative basal cell carcinoma. According to the authors, this case qualifies as a first to report a complete remission for this subset of skin cancer. Basal cell carcinoma (BCC) is one of the most common types of skin cancer. For patients with locally
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Human papillomavirus (HPV) is responsible for causing cervical cancer in many women worldwide, and successful screening programs have been accredited with helping to increase the capacity to identify and treat precancerous and pre-invasive disease. Quantitative methylation of the POU4F3 gene biomarker is a valuable tool for high-grade CIN detection. Cervical cancer, caused by the human
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Cancer encompasses a range of diseases with varying mortality rates. A recent study has shown how cancer mortality rates have changed and influenced life expectancy over 30 years and have uncovered discrepancies in cancer control efforts between different populations. Cancer is predicted to become the primary cause of global morbidity and mortality, surpassing cardiovascular disease
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A recent study in JAMA Oncology compared the effectiveness of mammography alone vs. mammography in combination with MRI or ultrasonography in breast cancer screening. The results showed that combinatorial approaches could have a significant impact on detection rates and sensitivity for patients undergoing screening for recurrence. Breast cancer screening is an indispensable practice in the
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Long-term androgen deprivation therapy (ADT) in combination with abiraterone, a selective inhibitor of CYP17, an enzyme needed for androgen production, is associated with significantly higher rates of overall and failure-free survival than ADT alone among men with locally advanced or metastatic prostate cancer. Cancer of the prostate is the most prevalent disease in men, with
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The benefits of sentinel lymph node biopsy in treating skin cancer (melanoma) is well established; however, the value of lymph-node dissection, a procedure in which all nodes located nearby metastasis-positive sentinel nodes are surgically removed, remains controversial. Recently, a phase III clinical trial demonstrated that immediate completion lymph-node dissection is not associated with increased melanoma-specific
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